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Sunday, December 5, 2021

Vaccines to pills: Health authorities worldwide tap into alternative Covid-19 treatments

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The UK has approved the world’s first pill to fight Covid-19 after clinical trials found it to be effective. 

Britain has become the first country in the world to approve the groundbreaking Covid-19 pill, as Pfizer has also announced results of studies for its own tablets.

Developed by American pharmaceutical Merck & Co Inc (Merck) and biotechnology company Ridgeback Biotherapeutics, the new molnupiravir drug, has been recommended by the the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) for use in people with moderate Covid-19 who are at risk of developing serious illnesses.

The pill is to be administered following a positive Covid-19 test, and within a five day period, twice a day, health authorities in the UK have advised.

Molnupiravir, known under the name of Lagevrio in the UK, is designed to introduce errors into the genetic code of the virus that causes the novel coronavirus.

This is the first such approval for an oral antiviral treatment for Covid-19. American advisers will meet on 30 November to review the drug’s safety, as well as efficacy data, and take a vote on whether it should be authorised.

The marks a new direction for treatments used to tackle the global health crisis, which has so far claimed the lives of over 5.2 million people. So far, vaccines have been at the forefront of prevention.

Molnupiravir has been closely monitored after data last month revealed it could halve the chances of dying or being hospitalised for high-risk individuals, protecting them from developing severe Covid-19 if administered early in the illness.

For now, the drug will be administered to patients at higher risk of complications in the UK. A wider rollout will come about if molnupiravir is clinically and cost effective in reducing hospitalisations and death.

Is the Covid-19 vaccine safe for kids below 11?

Merck has expressed that it expects to produce 10 million courses of the drug by the end of this year and at least 20 million in 2022.

The pharmaceutical company’s shares rose 2.1% to close at $90.54 on Thursday. Drug-makers such as Pfizer and Roche are in the race to develop a similar antiviral pills to fight again Covid-19.

In March, Pfizer started human safety testing for Covid-19 medication that could treat coronavirus when symptoms first arrive.

Pfizer’s drug, Paxlovid, has been shown to cut the risk of hospitalisation or death by 89% in vulnerable adults according to clinical trial results.

The UK has already ordered 250,000 courses of Paxlovid, which has not yet been approved, along with another 480,000 courses of molnupiravir.

Viral sequencing conducted so far has shown that molnupiravir is effective against all variants of SARS-CoV-2, including the deadly Delta variant.

As for Paxlovid, the drug is designed to block an enzyme that the coronavirus needs to multiply. The drug is meant to be taken alongside a low dose of another antiviral pill called ritonavir in order to remain in the body for longer.

The Pfizer pill has yet to be approved, and the pharmaceutical giant said it plans to submit interim trial results for to Food and Drug Administration as part of the emergency use application it started last month.

Merck expressed its commitment to providing timely access to its drug globally as it plans for tiered pricing aligned with a nation’s ability to pay.

The company has also licensed the drug to generic drugmakers to supply low-income countries with the medication.

Here in Qatar, authorities have yet to make any announcements on plans to roll out capsules to tackle the ongoing pandemic. However, decisions in the Gulf state have been made following FDA approvals.

Earlier this month, a Qatar-based health official said on Qatar TV that the US Food and Drug Administration approval of the emergency use of Pfizer’s coronavirus vaccine for children aged 5 to 11 “gives the green light” for countries to follow suit.

So far, a total of 4,859,929 doses have been administered in Qatar, where 84.5% of the population have already received both doses. Currently, health authorities are prioritising society’s most vulnerable for the third Covid-19 shot.

Qatar is currently dealing with a total of 1,453 active Covid-19 cases. Since the start of the global health crisis, 611 people have died from the coronavirus in the Gulf state.


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